Which Allergy Medicine Is Right for Me?

When allergies hit, you just want relief. But standing in the pharmacy aisle staring at rows of boxes — antihistamines, decongestants, sprays, pills — can feel overwhelming.

“The good news is there’s almost always an allergy medicine that will work for you,” says Syed Hussain, MD, medical director at Hartford HealthCare Urgent Care. “The key is finding the one that matches your symptoms.”

Here’s how to choose the right option — and when to talk to your doctor.

Antihistamines: Best for sneezing and itchy eyes.

If your main symptoms are sneezing, a runny nose, or watery, itchy eyes, start with an antihistamine.

“These block histamine — the chemical behind many allergy symptoms,” Dr. Hussain says. “Over-the-counter options like cetirizine (Zyrtec), loratadine (Claritin), or fexofenadine (Allegra) are good for daytime use, though some, like Zyrtec, may cause drowsiness. Diphenhydramine (Benadryl) works quickly but can make you sleepy, so it’s best for nighttime.”

> Related: 6 Foods That Could Help Your Spring Allergies

Decongestants: Best for a stuffy nose.

If you’re completely clogged, a decongestant can help shrink swollen nasal passages.

“Look for ingredients like pseudoephedrine or phenylephrine,” Dr. Hussain says. “They can bring quick relief, but may also raise blood pressure or cause jitteriness, so they’re not for everyone. If you have high blood pressure or heart problems, check with your doctor first.”

Nasal sprays: Best for long-term control.

Steroid nasal sprays like fluticasone (Flonase) or triamcinolone (Nasacort) reduce inflammation inside the nose, especially for people with year-round allergies.

“They don’t work instantly, but daily use can prevent symptoms before they start,” says Dr. Hussain. “For many people, combining a nasal spray with another allergy medicine gives the best relief.”

Eye drops: Best for itchy, watery eyes.

Over-the-counter allergy eye drops can ease redness, itching, and tearing.

“They’re a good add-on if eye symptoms are your main concern,” Dr. Hussain notes. “Often, oral antihistamines help with seasonal allergy-related eye issues. But if you have conditions like glaucoma, check with your eye doctor before using allergy eye drops, as they can raise eye pressure.”

> Related: Why Your Allergies Might Be Worse in the Fall (or the Spring)

When to talk to your doctor.

If you’ve tried over-the-counter allergy medicine and still can’t find relief, or your symptoms are severe:

“There are prescription options, allergy testing, and even treatments like immunotherapy that can help long-term,” Dr. Hussain says.

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